Services and Products
Chemistry Services
Hit to Lead and Lead Optimization
Our Medicinal Chemistry Department has extensive expertise and successful track records in early stage drug discovery including hit identification, hit to lead optimization, computer-aided drug design, lead selection and optimization, as well as ADME/Tox profile improvement for the discovery of small-molecule drugs. This enables our clients to develop effective, patentable, and safe drugs.
Teams at Granlen utilize both combinatorial and traditional approaches to optimize lead compounds for structure-activity relationships (SAR) studies by leveraging our vast medicinal chemistry knowledge. Further, our teams can design and synthesize advanced leads to optimize potency, selectivity and specificity, and to improve ADME-Tox profiles and deliverability to provide your preclinical candidate.
Granlen’s experienced computational group can provide Structure/Ligand-based drug design with cutting edge technologies, such as, HTS data analysis, scaffold-based compound classification, and 2D or 3D-based virtual screening.