Services and Products
Development Services
Drug Metabolism and Pharmacokinetics
We conduct drug metabolism, pharmacokinetics (PK) and toxicokinetic (TK) studies in vitro & in vivo to evaluate drug properties. Our services are recognized as FDA/SFDA compliant.
Services/Capabilities:
- Routine pharmocokinetic (PK) and toxicokinetic (TK) studies in rats, beagle dogs, and monkeys
- Absorption, tissue distribution, and excretion
- Metabolite profiling, identification, and characterization
- Drug interaction (CYPs, UGTs, and transporters)
- Plasma protein binding
- Metabolic stability
- Bioavailability in animals
Available Biological Models
- Caco-2, Bcap37/MDR1, MDCK/MDR1, K562 and K562/ADR cell lines
- Fluorometric CYP isoforms inhibition assays (1A2, 2C9, 2D6, 2E1, 3A4 etc)
- Recombinant Drug Metabolizing Enzymes (CYP: 1A2, 3A4, 2A5, 2A6, 2A13, 2B6, 2C9, 2C18, 2C19, 2D6, 2E1 etc, and UGT: 1A1, 1A3, 1A4, 1A6, 1A9, 2B7, 2B15 etc)
- Hepatic microsome and primary cultured hepatocytes (human, monkey, rat)
- PXR and CAR Reporter Gene Assays
- In situ single-pass intestinal perfusion (SPIP) and perfusing ligated intestinal segment models